Erectile dysfunction, or ED, is a distressing condition that can put a strain on a couple. Often, men will avoid sexual situations and this can cause their partner to feel rejected or insecure. Fortunately, there is effective treatment available. Two studies were carried out to determine how a 50mg and 100mg dose of a popular PDE5 inhibitor would affect sexual performance.
A Comparison of Different Doses
The men received a dose of 50mg sildenafil citrate to be taken as needed before sexual intercourse in the first study. After 2 weeks, those who tolerated the medication well had their dose increased to 100mg for the second study. The effect that each dose had on erection hardness was assessed. The Erection Hardness Score (EHS) was used in the research and this allows men to rate their erections on a scale of 0 to 4. A score of 0 indicates no erection and 4 is a completely hard erection.
Compared with inactive placebo tablets, the percentage of EHS4erections was higher for both 50mg and 100mg sildenafil doses. However, the men who increased their dose to 100mg sildenafil citrate had a higher percentage of EHS 4 scores than those who took 50mg. The men who took 100mg also had a higher rate of successful sexual intercourse encounters. The study concluded that a 100mg dose should be advised if a patient is unable to attain a completely hard erection with a 50mg dose.
How This PDE5 Inhibitor Works
This medication blocks an enzyme in the body called PDE5. The smooth muscle cells lining the blood vessels of the penis contain particularly high concentrations of PDE5. This enzyme degrades another molecule called cGMP and this also reduces nitric oxide production. Nitric oxide is essential for erections as it relaxes blood vessels and promotes optimal blood flow. By blocking PDE5, sildenafil citrate increases cGMP, boosts the production of nitric oxide and causes erections to become firmer.
Expert Advice for Safe Usage
· Avoid taking more than one tablet at a time and do not take this medication in combination with another medication used to treat ED.
· Avoid the use of riociguat and other medications called nitrates.
· If you plan to take this medication, do not consume more than two units of alcohol.
Recommendations for Best Results
· This medication should be taken with some water, preferably on an empty stomach.
· Take a sildenafil citrate tablet about one hour before sexual activity so it has enough time to become entirely effective.
· The duration of effect is 4-6 hours and this medication works in response to sexual stimulation.
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